Regös, Roland Robert, Prof. Dr.

Prof. Dr. Roland Robert Regös

Institut für Integrative Biologie 

CHN  H 76.2 

Universitätstrasse 16

8092 Zürich

Switzerland

  • phone +41 44 632 69 35 
  • fax +41 44 632 12 71 
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Additional information

Course Catalogue

Autumn Semester 2017

Number Unit
701-0263-01L Seminar in Evolutionary Ecology of Infectious Diseases 

Short CV

I was born in Budapest and was raised in Germany. I did my undergraduate degree in physics at Munich University. After my diploma in 1996, I switched to theoretical biology. I studied with Martin Nowak at Oxford University for a MSc degree and with Sebastian Bonhoeffer at the ETH Zurich for a PhD. From 2001 until 2005, I worked with Rustom Antia, Silvija Staprans, Mark Feinberg, and Bruce Levin at Emory University.
After my postdoc I came back to Zurich and joined the Theoretical Biology group of Sebastian Bonhoeffer as a senior postdoc. Since 2007, I have been leading a small research group in mathematical immunology and virology with funding from the Swiss National Science Foundation. In 2011, I became a "Privatdozent".

Research Interests

My research focuses on the population biology of infectious diseases. I use mathematical models to address questions that concern mostly the within-host dynamics of pathogens --- how they replicate, how they ellicit immune responses and how they are controlled. I focus on HIV, SIV and LCMV infections, but have also been studying poliovirus, CMV, influenza virus and E. coli.
In addition, I am interested in the between-host dynamics and the evolutionary ecology of host-parasite systems. In this context, I have been studying, for example, how new infectious diseases emerge, and if the use of antivirals will lead to the rise of viral resistance during influenza pandemics.

Research group page

Publications

2016    |   2015    |   2014    |   2013    |   2012    |   Before 2012    |  


2016

Kaiser P, Roland Regoes, Hardt WD
Population Dynamics Analysis of Ciprofloxacin-Persistent S. Typhimurium Cells in a Mouse Model for Salmonella Diarrhea.

2016, Methods Mol Biol
DOI 

Rusert P, Kouyos RD, Kadelka C, Ebner H, Schanz M, Huber M, Braun DL, Nathanaël Hozé, Scherrer A, Magnus C, Weber J, Uhr T, Cippa V, Thorball CW, Kuster H, Cavassini M, Bernasconi E, Hoffmann M, Calmy A, Battegay M, Rauch A, Yerly S, Aubert V, Klimkait T, Böni J, Fellay J, Roland Regoes, Günthard HF, Trkola A
Determinants of HIV-1 broadly neutralizing antibody induction.

2016, Nat Med
DOI 

Victor Garcia, Feldman MW, Roland Regoes
Investigating the Consequences of Interference between Multiple CD8+ T Cell Escape Mutations in Early HIV Infection.

2016, PLoS Comput Biol
PDF    DOI 


2015

Roland Regoes, Magnus C
The role of chance in primate lentiviral infectivity: from protomer to host organism.

2015, Prog Mol Biol Transl Sci
DOI 

Brandenberg OF, Magnus C, Roland Regoes, Trkola A
The HIV-1 Entry Process: A Stoichiometric View.

2015, Trends Microbiol
DOI 

Maier L, Diard M, Sellin ME, Chouffane ES, Trautwein-Weidner K, Periaswamy B, Slack E, Dolowschiak T, Stecher B, Loverdo C, Roland Regoes, Hardt WD
Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis.

2015, PLoS Pathog
PDF    DOI 

Rahnamaeian M, Cytryńska M, Zdybicka-Barabas A, Dobslaff K, Wiesner J, Twyman RM, Zuchner T, Sadd BM, Roland Regoes, Schmid-Hempel P, Vilcinskas A
Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria.

2015, Proc Biol Sci
PDF    DOI 

Victor Garcia, Richter K, Graw F, Oxenius A, Roland Regoes
Estimating the In Vivo Killing Efficacy of Cytotoxic T Lymphocytes across Different Peptide-MHC Complex Densities.

2015, PLoS Comput Biol
PDF    DOI 

Johnson S, Bergthaler A, Graw F, Flatz L, Bonilla WV, Siegrist CA, Lambert PH, Roland Regoes, Pinschewer DD
Protective efficacy of individual CD8+ T cell specificities in chronic viral infection.

2015, J Immunol
PDF    DOI 

Brandenberg OF, Magnus C, Rusert P, Roland Regoes, Trkola A
Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry.

2015, PLoS Pathog
PDF    DOI 


2014

Victor Garcia, Roland Regoes
The Effect of Interference on the CD8(+) T Cell Escape Rates in HIV.

2014, Front Immunol
PDF    DOI 

Brandenberg OF, Rusert P, Magnus C, Weber J, Böni J, Günthard HF, Roland Regoes, Trkola A
Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation.

2014, Retrovirology
PDF    DOI 

Maier L, Diard M, Sellin ME, Chouffane ES, Trautwein-Weidner K, Periaswamy B, Slack E, Dolowschiak T, Stecher B, Loverdo C, Roland Regoes, Hardt WD
Granulocytes impose a tight bottleneck upon the gut luminal pathogen population during Salmonella typhimurium colitis.

2014, PLoS Pathog
PDF    DOI 

Roland Regoes, McLaren PJ, Battegay M, Bernasconi E, Calmy A, Günthard HF, Hoffmann M, Rauch A, Telenti A, Fellay J
Disentangling human tolerance and resistance against HIV.

2014, PLoS Biol
PDF    DOI 

Predicting the impact of CD8+ T cell polyfunctionality on HIV disease progression.

2014, J Virol
PDF    DOI 

Kaiser P, Roland Regoes, Dolowschiak T, Wotzka SY, Lengefeld J, Slack E, Grant AJ, Ackermann M, Hardt WD
Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment.

2014, PLoS Biol
PDF    DOI 


2013

Seich Al Basatena NK, Chatzimichalis K, Graw F, Frost SD, Roland Regoes, Asquith B
Can non-lytic CD8+ T cells drive HIV-1 escape?

2013, PLoS Pathog
PDF    DOI 

Magnus C, Brandenberg OF, Rusert P, Trkola A, Roland Regoes
Mathematical models: a key to understanding HIV envelope interactions?

2013, J Immunol Methods
DOI 

Kaiser P, Slack E, Grant AJ, Hardt WD, Roland Regoes
Lymph node colonization dynamics after oral Salmonella Typhimurium infection in mice.

2013, PLoS Pathog
PDF    DOI 

Diard M, Victor Garcia, Maier L, Remus-Emsermann MN, Roland Regoes, Ackermann M, Hardt WD
Stabilization of cooperative virulence by the expression of an avirulent phenotype.

2013, Nature
DOI 

Roland Regoes, Hamblin S, Tanaka MM
Viral mutation rates: modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed.

2013, Proc Biol Sci
PDF    DOI 


2012

Influence of the fibroblastic reticular network on cell-cell interactions in lymphoid organs.

2012, PLoS Comput Biol
PDF    DOI 

The role of exposure history on HIV acquisition: insights from repeated low-dose challenge studies.

2012, PLoS Comput Biol
PDF    DOI 


Before 2012

top 

Graw F, Richter K, Oxenius A, Roland Regoes
Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection.

2011, Proc Biol Sci
PDF    DOI 

Magnus C, Roland Regoes
Restricted occupancy models for neutralization of HIV virions and populations.

2011, J Theor Biol
DOI 

Rusert P, Krarup A, Magnus C, Brandenberg OF, Weber J, Ehlert AK, Roland Regoes, Günthard HF, Trkola A
Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies.

2011, J Exp Med
PDF    DOI 

Johnson PL, Kochin BF, McAfee MS, Stromnes IM, Roland Regoes, Ahmed R, Blattman JN, Antia R
Vaccination alters the balance between protective immunity, exhaustion, escape, and death in chronic infections.

2011, J Virol
PDF    DOI 

Ruprecht CR, Krarup A, Reynell L, Mann AM, Brandenberg OF, Berlinger L, Abela IA, Roland Regoes, Günthard HF, Rusert P, Trkola A
MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1.

2011, J Exp Med
PDF    DOI 

zur Wiesch PA, Kouyos R, Engelstädter J, Roland Regoes, Sebastian Bonhoeffer
Population biological principles of drug-resistance evolution in infectious diseases.

2011, Lancet Infect Dis
DOI 

Samuel Alizon, Luciani F, Roland Regoes
Epidemiological and clinical consequences of within-host evolution.

2011, Trends Microbiol
DOI 

Kouyos RD, Gordon SN, Staprans SI, Silvestri G, Roland Regoes
Similar impact of CD8+ T cell responses on early virus dynamics during SIV infections of rhesus macaques and sooty mangabeys.

2010, PLoS Comput Biol
PDF    DOI 

Graw F, Magnus C, Roland Regoes
Theoretical analysis of the evolution of immune memory.

2010, BMC Evol Biol
PDF    DOI 

Magnus C, Roland Regoes
Estimating the stoichiometry of HIV neutralization.

2010, PLoS Comput Biol
PDF    DOI 

Ben-Ami F, Ebert D, Roland Regoes
Pathogen dose infectivity curves as a method to analyze the distribution of host susceptibility: a quantitative assessment of maternal effects after food stress and pathogen exposure.

2010, Am Nat
DOI 

Investigating CTL mediated killing with a 3D cellular automaton.

2009, PLoS Comput Biol
PDF    DOI 

Fouchet D, Roland Regoes
A population dynamics analysis of the interaction between adaptive regulatory T cells and antigen presenting cells.

2008, PLoS One
PDF    DOI 

Ben-Ami F, Roland Regoes, Ebert D
A quantitative test of the relationship between parasite dose and infection probability across different host-parasite combinations.

2008, Proc Biol Sci
PDF    DOI 

Yates A, Graw F, Barber DL, Ahmed R, Roland Regoes, Antia R
Revisiting estimates of CTL killing rates in vivo.

2007, PLoS One
PDF    DOI 

Mandl JN, Roland Regoes, Garber DA, Feinberg MB
Estimating the effectiveness of simian immunodeficiency virus-specific CD8+ T cells from the dynamics of viral immune escape.

2007, J Virol
PDF    DOI 

Roland Regoes, Yates A, Antia R
Mathematical models of cytotoxic T-lymphocyte killing.

2007, Immunol Cell Biol
DOI 

Roland Regoes, Barber DL, Ahmed R, Antia R
Estimation of the rate of killing by cytotoxic T lymphocytes in vivo.

2007, Proc Natl Acad Sci U S A
PDF    DOI 

Yates A, Antia R, Roland Regoes
How do pathogen evolution and host heterogeneity interact in disease emergence?

2006, Proc Biol Sci
PDF    DOI 

Bull JJ, Roland Regoes
Pharmacodynamics of non-replicating viruses, bacteriocins and lysins.

2006, Proc Biol Sci
PDF    DOI 

Handel A, Roland Regoes, Antia R
The role of compensatory mutations in the emergence of drug resistance.

2006, PLoS Comput Biol
PDF    DOI 

Roland Regoes, Bowen EF, Cope AV, Gor D, Hassan-Walker AF, Prentice HG, Johnson MA, Sweny P, Burroughs AK, Griffiths PD, Sebastian Bonhoeffer, Emery VC
Modelling cytomegalovirus replication patterns in the human host: factors important for pathogenesis.

2006, Proc Biol Sci
PDF    DOI 

Roland Regoes, Longini IM, Feinberg MB, Staprans SI
Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challenges.

2005, PLoS Med
PDF    DOI 

Wiuff C, Zappala RM, Roland Regoes, Garner KN, Baquero F, Levin BR
Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations.

2005, Antimicrob Agents Chemother
PDF    DOI 

Roland Regoes, Crotty S, Antia R, Tanaka MM
Optimal replication of poliovirus within cells.

2005, Am Nat
DOI 

Roland Regoes, Wiuff C, Zappala RM, Garner KN, Baquero F, Levin BR
Pharmacodynamic functions: a multiparameter approach to the design of antibiotic treatment regimens.

2004, Antimicrob Agents Chemother
PDF    DOI 

Roland Regoes, Antia R, Garber DA, Silvestri G, Feinberg MB, Staprans SI
Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection.

2004, J Virol
PDF    DOI 

Antia R, Roland Regoes, Koella JC, Bergstrom CT
The role of evolution in the emergence of infectious diseases.

2003, Nature
DOI 

Roland Regoes, Hottinger JW, Sygnarski L, Ebert D
The infection rate of Daphnia magna by Pasteuria ramosa conforms with the mass-action principle.

2003, Epidemiol Infect
DOI 

Roland Regoes, Wodarz D, Nowak MA
Virus dynamics: the effect of target cell limitation and immune responses on virus evolution.

1998, J Theor Biol
DOI 

 
 
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27.07.2017
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