Hall, Alex, Prof. Dr.

Prof. Dr. Alex Hall

Professur für Pathogenökologie

CHN  D 35.1 

Universitätstrasse 16

8092 Zürich


  • phone +41 44 632 71 13 
  • mail
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Research interests

I am currently working on:


  • How the abiotic environment influences bacteria-virus interactions (with Pauline Scanlan)
  • Resistance phenotypes of natural and clinical isolates of bacteria (with Richard Allen)
  • Effect of dead cells on growth and evolution (with Fokko Smakman)
  • Antibiotic resistance evolution in ecologically complex systems (with Flor Arias Sánchez)
  • Statistical methods for inferring coevolutionary dynamics (with Angus Buckling)

Short CV

15 Assistant Professor at ETH Zürich

14 Junior Group Leader (SNSF Ambizione Fellow) at ETH Zürich

12-14 Marie Curie Intra-European Fellowship at ETH Zürich

11 Postdoc at ETH Zürich with Martin Ackermann and Sebastian Bonhoeffer

09-11 Postdoc at University of Oxford with Angus Buckling

05-09 PhD at University of Edinburgh with Nick Colegrave



Parasite genetic distance and local adaptation in co-evolving bacteria-bacteriophage populations
Pauline D. Scanlan, Alex R. Hall and Angus Buckling
Molecular Ecology, 26 (7): 1747-1755, Oxford: Wiley-Blackwell, 2017.
Modification of Escherichia coli-bacteriophage interactions by surfactants and antibiotics in vitro
Pauline D. Scanlan, Anna M. Bischofberger and Alex R. Hall
FEMS Microbiology Ecology, 93 (1): fiw211, Oxford: Oxford University Press, 2017.


Effects of antibiotic resistance alleles on bacterial evolutionary responses to viral parasites
Flor I. Arias-Sánchez and Alex R. Hall
Biology Letters, 12 (5): 20160064, London: The Royal Society, 2016.
Adaptation to parasites and costs of parasite resistance in mutator and non-mutator bacteria
Sébastien Wielgoss, Tobias Bergmiller, Anna M. Bischofberger and Alex R. Hall
Molecular Biology and Evolution, 33 (3): 770-782, Oxford: Oxford University Press, 2016.


Spatial heterogeneity lowers rather than increases host-parasite specialization
E. Hesse, Alex Best, Mike Boots, Alex R. Hall and Angus Buckling
Journal of Evolutionary Biology, 28 (9): 1682-1690, Oxford: Wiley-Blackwell, 2015.
Costs of antibiotic resistance – separating trait effects and selective effects
Alex R. Hall, Daniel C. Angst, Konstanze T. Schiessl and Martin Ackermann
Evolutionary Applications, 8 (3): 261-272, Oxford: Wiley, 2015.
Interspecific interactions drive chitin and cellulose degradation by aquatic microorganisms
Gianluca Corno, Ivette Salka, Kirsten Pohlmann, Alex R. Hall and Hans-Peter Grossart
Aquatic Microbial Ecology, 76 (1): 27-37, Oldendorf/Luhe: Inter-Research, 2015.
Parasite host range and the evolution of host resistance
Florien A. Gorter, Alex R. Hall, Angus Buckling and Pauline D. Scanlan
Journal of Evolutionary Biology, 28 (5): 1119-1130, Oxford: Wiley-Blackwell, 2015.
Experimental evolution and bacterial resistance: (co)evolutionary costs and trade-offs as opportunities in phage therapy research
Pauline D. Scanlan, Angus Buckling and Alex R. Hall
Bacteriophage, 5 (2): e1050153, Philadelphia, PA: Taylor & Francis, 2015.
Coevolution with bacteriophages drives genome-wide host evolution and constrains the acquisition of abiotic-beneficial mutations
Pauline D. Scanlan, Alex R. Hall, Gordon Blackshields, Ville-P. Friman, Michael R. Davis, Joanna B. Goldberg and Angus Buckling
Molecular Biology and Evolution, 32 (6): 1425-1435, Oxford: Oxford University Press, 2015.
Lytic phages obscure the cost of antibiotic resistance in Escherichia coli
Samuel J. Tazzyman and Alex R. Hall
The ISME Journal, 9 (4): 809-820, Basingstoke: Nature, 2015.


Higher resources decrease fluctuating selection during host-parasite coevolution
Laura Lopez Pascua, Alex R. Hall, Andrew D. Morgan, Mike Boots and Angus Buckling
Ecology Letters, 17 (11): 1380-1388, Oxford: Wiley-Blackwell, 2014.
Tetracycline modifies competitive interactions in experimental microcosms containing bacteria isolated from freshwater
Alex R. Hall and Gianluca Corno
FEMS microbiology ecology, 90 (1): 168-174, London: Wiley-Blackwell, 2014.


The role of ‘soaking’ in spiteful toxin production in Pseudomonas aeruginosa
R. Fredrik Inglis, Alex R. Hall and Angus Buckling
Biology Letters, 9 (1): 20120569, London: The Royal Society, 2013.
No effect of host–parasite co-evolution on host range expansion
Pauline D. Scanlan, Alex R. Hall, Peter Burlinson, Gail Preston and Angus Buckling
Journal of evolutionary biology, 26 (1): 205-209, Oxford: Wiley-Blackwell, 2013.
The cost of antibiotic resistance depends on evolutionary history in Escherichia coli
Daniel C. Angst and Alex R. Hall
BMC Evolutionary Biology, 13 (1): 163, London, UK: Biomed. Central LTD, 2013.
Genotype-by-environment interactions due to antibiotic resistance and adaptation in Escherichia coli
Alex R. Hall
Journal of evolutionary biology, 26 (8): 1655-1664, Oxford, UK: Wiley-Blackwell, 2013.


Multiplicity of infection does not accelerate infectivity evolution of viral parasites in laboratory microcosms
Alex R. Hall, Pauline D. Scanlan, Helen C. Leggett and Angus Buckling
Journal of Evolutionary Biology, 25 (2): 409-415, Oxford: Wiley-Blackwell, 2012.
Effects of sequential and simultaneous applications of bacteriophages on populations of Pseudomonas aeruginosa in vitro and in wax moth larvae
Alex R. Hall, Daniel De Vos, Ville-Petri Friman, Jean-Paul Pirnay and Angus Buckling
Applied and Environmental Microbiology, 78 (16): 5646-5652, Washington: American Society for Microbiology, 2012.
Diversity-disturbance relationships: frequency and intensity interact
Alex R. Hall, Adam D. Miller, Helen C. Leggett, Stephen H. Roxburgh, Angus Buckling and Katriona Shea
Biology Letters, 8 (5): 768-771, London: The Royal Society, 2012.


The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase
Alex R. Hall, James C. Iles and R. Craig MacLean
Genetics, 187 (3): 817-822, Bethesda, Maryland: Genetics Society of America, 2011.
Epistasis buffers the fitness effects of rifampicin-resistance mutations in Pseudomonas aeruginosa
Alex R. Hall and R. Craig MacLean
Evolution, 65 (8): 2370-2379, Oxford: Wiley-Blackwell, 2011.
Bacteria-phage coevolution and the emergence of generalist pathogens
Alex R. Hall, Pauline D. Scanlan and Angus Buckling
American Naturalist, 177 (1): 44-53, Chicago: University of Chicago Press, 2011.
Host-parasite coevolutionary arms races give way to fluctuating selection
Alex R. Hall, Pauline D. Scanlan, Andrew D. Morgan and Angus Buckling
Ecology Letters, 14 (7): 635-642, Oxford: Wiley-Blackwell, 2011.
Genetic basis of infectivity evolution in a bacteriophage
Pauline D. Scanlan, Alex R. Hall, Laura Lopez Pascua and Angus Buckling
Molecular Ecology, 20 (5): 981-989, Oxford: Wiley-Blackwell, 2011.


Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa
Alex R. Hall, Victoria F. Griffiths, R. Craig Maclean and Nick Colegrave
Proceedings of the Royal Society B: Biological Sciences, 277 (1681): 643-650, London: The Royal Society, 2010.
The evolution of antibiotic resistance: Insight into the roles of molecular mechanisms of resistance and treatment context
R. Craig MacLean, Alex R. Hall, Gabriel G. Perron and Angus Buckling
Discovery Medicine, 10 (51): 112-118, Timonium, MD: Discovery Medicine, 2010.
The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts
R. Craig MacLean, Alex R. Hall, Gabriel G. Perron and Angus Buckling
Nature Reviews Genetics, 11 (6): 405-414, London: Nature Publishing Group, 2010.
Hypermutability and compensatory adaptation in antibiotic-resistant bacteria
Gabriel G. Perron, Alex R. Hall and Angus Buckling
American Naturalist, 176 (3): 303-311, Chicago, IL: University of Chicago Press, 2010.


Decay of unused characters by selection and drift
Alex R. Hall and Nick Colegrave
Journal of Evolutionary Biology, 21 (2): 610-617, Oxford: Wiley-Blackwell, 2008.
Selection for predator resistance varies with resource supply in a model adaptive radiation
Alex R. Hall, Justin R. Meyer and Rees Kassen
Evolutionary Ecology Research, 10 (5): 735-746, Tuscon: Evolutionary Ecology, 2008.


How does resource supply affect evolutionary diversification?
Alex R. Hall and Nick Colegrave
Proceedings of the Royal Society B: Biological Sciences, 274 (1606): 73-78, London: The Royal Society, 2007.
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