Legros, Mathieu, Dr.

ETH Zürich Dr. Mathieu Legros Institut f. Integrative Biologie CHN H 74 Universitätstrasse 16 8092 Zürich Phone: +41 44 632 22 17 E-Mail:

Research interests

Broadly speaking, I study mosquito-borne diseases and mosquito ecology, using theoretical approaches including mathematical models and computer simulations.
My current research focuses on the evolution of resistance to antimalarial drugs, integrating malaria epidemiology, within-host and within-vector dynamics and vector ecology to characterize the conditions leading to resistance arising and spreading.

Short CV

• 2011-Present: Postdoctoral Researcher, Institute für Integrative Biologie, ETH Zürich, Switzerland (Sebastian Bonhoeffer)
• 2010-2011: Postdoctoral Research Associate, Dept. of Entomology, UC Davis, CA, USA (Tom Scott)
• 2006-2011: Postdoctoral Research Associate, Dept. of Entomology, North Carolina State U, NC, USA (Fred Gould and Alun Lloyd)
• 2001-2006: PhD, Laboratoire de Parasitologie Evolutive, Université Paris 6, France (Jacob Koella)
• 2000-2001: MSc, Laboratoire de Parasitologie Evolutive, Université Paris 6, France (Jacob Koella)

Publications

In review

• Legros M., Xu C., Scott T.W., Morrison A.C., Lloyd A.L. & Gould F. Assessing the feasibility of controlling Aedes aegypti with transgenic methods: A model-based evaluation. Nat. Commun. In review.
• Robert M., Legros M., Facchinelli L., Valerio L., Ramsey J.M., Scott T.W., Gould F. & Lloyd A.L. Mathematical models as aids for design and interpretation of experiments: The case of transgenic mosquitoes. J. Med. Entomol. In review.

Published or in press

• Legros M., Magori K., Morrison A.C., Xu C., Scott T.W., Lloyd A.L. & Gould F. (2011) Evaluation of location-specific predictions by a detailed simulation model of Aedes aegypti populations. PLoS One, 6(7): e22701.
• Huang Y., Lloyd A.L., Legros M. & Gould F. (2011) Gene-drive into insect populations with age and spatial structure: a theoretical assessment. Evol. Appl., 4(3): 415-428.
• Xu C., Legros M., Gould F. & Lloyd A.L. (2010) Understanding uncertainties in model-based predictions of Aedes aegypti population dynamics. PLoS Negl. Trop. Dis., 4(9): e830.
• Legros M. & Koella J.C. (2010) Experimental evolution of specialization by a microsporidian parasite. BMC Evol. Biol., 10:159.
• Jongsma M.A., Gould F., Legros M., Yang L., van Loon J.J.A. & Dicke M. (2010) Insect oviposition behavior affects the evolution of adaptation to Bt crops: consequences for refuge policies. Evol. Ecol., 24(5): 1017-1030.
• Legros M., Lloyd A.L., Huang Y. & Gould F. (2009) Density-dependent intraspecific competition in the larval stage of Aedes aegypti (Diptera: Culicidae): Revisiting the current paradigm. J. Med. Entomol., 46(3): 409-419.
• Magori K.*, Legros M.*, Puente M., Focks D.A., Scott T.W., Lloyd A.L. & Gould F. (2009) Skeeter Buster: a stochastic, spatially-explicit modeling tool for studying Aedes aegypti population replacement and population suppression strategies. PLoS Negl. Trop. Dis. 3(9): e508.
• Huang Y., Lloyd A.L., Legros M. & Gould F. (2009) Gene drive in age-structured populations. Evol. Appl., 2(2):143-159.
• Gould F., Huang Y., Legros M. & Lloyd A.L. (2008) A killer-rescue system for self-limiting gene drive of anti-pathogen constructs. Proc. R. Soc. B, 275, 2823-9.
• Fournel S., Huc X., Aguerre-Gire M., Solier C., Legros M., Praud-Brethenou C., Moussa M., Chaouat G., Berrebi A., Bensussan A., Lenfant F. & Le Bouteiller P. (2000) Comparative reactivity of different HLA-G monoclonal antibodies to soluble HLA-G molecules, Tissue Antigens, 55(6) : 510-8.

Personal website

For more info: http://legrosmathi.eu