Hall, Alex, Dr.

Research Interests

I study microbial evolution, with a particular focus on bacterial resistance to antibiotics and bacteria-virus interactions. Current projects include: (1) what happens to antibiotic-resistant bacteria when we remove the antibiotics?, (2) how does viral parasitism influence the evolution of antibiotic-resistant bacteria?, and (3) are the genetic mechanisms associated with resistance and compensatory adaptation specific to genotypes/environments? To answer these questions I study evolution in real time in experimental populations of microbes. I am a member of the Theoretical Biology (Prof. Bonhoeffer) and Molecular Microbial Ecology (Prof. Ackermann) groups. Marie Curie Intra-European Fellowship.

Publications

12. Hall, A.R., Scanlan, P.D., Morgan, A.D. & Buckling, A. 2011 Host-parasite coevolutionary arms races give way to fluctuating selection. Ecology Letters 14, 635-642.

11. Hall, A.R. & MacLean, R.C. 2011 Epistasis buffers the fitness effects of rifampicin resistance mutations in Pseudomonas aeruginosa. Evolution 65, 2370-2379.

10. Hall, A.R., Iles, J. & MacLean, R.C.M. 2011 The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase. Genetics 187, 817-822.

9. Hall, A.R., Scanlan, P.D. & Buckling, A. 2011 Bacteria-phage coevolution and the emergence of generalist pathogens. American Naturalist 177, 44-53.

8. Scanlan, P.D., Hall, A.R. & Buckling 2011. Genetic basis of infectivity evolution in a bacteriophage. Molecular Ecology 20, 981-989.

7. MacLean, R.C., Hall, A.R., Perron, G.G. & Buckling, A. 2010 The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts. Nature Reviews Genetics 11, 405-414.

6. Perron, G.G., Hall, A.R. & Buckling 2010 Hypermutability and compensatory adaptation in antibiotic-resistant bacteria. American Naturalist 176: 303-311.

5. MacLean, R.C., Hall, A.R., Perron, G.G. & Buckling, A. 2010 The evolution of antibiotic resistance: insight into the roles of molecular mechanisms of resistance and treatment context. Discovery Medicine 10: 112-118.

4. Hall, A.R., Griffiths, V.F., MacLean, R.C. & Colegrave, N. 2010 Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa. Proceedings of the Royal Society B 277, 643-650.

3. Hall, A.R., Meyer, J.R. & Kassen, R. 2008. Selection for predator resistance varies with resource supply in a model adaptive radiation. Evolutionary Ecology Research 10, 735-746.

2. Hall, A.R. & Colegrave, N. 2007. Decay of unused characters by selection and drift. Journal of Evolutionary Biology 21, 610-617.

1. Hall, A.R. & Colegrave, N. 2007. How does resource supply affect evolutionary diversification? Proceedings of the Royal Society B 274, 73-78.