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Evolutionary ecology of infectious diseases: Current topics
Topic of this year (Fall 2010): Evolution of Drug Resistance
In this course, we will discuss the molecular mechanisms and the population biology of resistance evolution, as well as strategies that can be taken to control the evolution of drug resistance. The course will be structured as follows:
0) Introduction (slides)
1) Bacteria (list of papers)
2) Viruses (list of papers)
3) Malaria (list of papers)
4) Agricultural pests (list of papers)
5) Cancer (list of papers)
Please click on the links above to find lists of papers relating to the respective group of organisms.
Schedule for the course:
| Date | Topic | Paper(s) | Responsible person | Presenting students | Summary |
| 1) Bacteria | |||||
| September 28 | Molecular mechanisms of resistance |
Alekshun, Cell 2007 MacLean, Nature Rev Genetics 2010 |
Roger Kouyos, Pia Abel zur Wiesch |
Paolo Ocampo | |
| October 5 | Epidemiology and population biology of bacterial resistance |
Levy & Marshall, Nature Medicine 2004 Lipsitch & Samore, EID 2002 |
Roger Kouyos |
Angelina Gmür Sorcha Mc Ginty |
[pdf] [pdf] |
| October 12 | Population-wide treatment strategies |
Bonhoeffer et al., PNAS 1997 Bergstrom et al., PNAS 2004 |
Roger Kouyos |
Gabriel Leventhal Isabel Griesemer |
[pdf] [pdf] |
| 2) Viruses | |||||
| October 19 |
Resistance in influenza |
Nelson et al., Virology 2009 Regös & Bonhoeffer, Science 2006 |
Roland Regös |
Dorita Avila Rojas Maria Gekenidis |
[pdf] [pdf] |
| October 26 | Resistance & mutagenesis |
Pfeiffer & Kirkegaard, PNAS 2003 Gerrish & Garcia-Lerma, Lancet Infect Dis 2003 |
Roland Regös |
Niv Sabath Helen Alexander |
[pdf] [pdf] |
| November 2 | Introduction to agricultural pathogens |
FRAC monograph Schnabel & Jones 1999 |
Sebastian Bonhoeffer |
Mark Lendenmann Simon Ineichen |
[pdf] [pdf] |
| 3) Malaria | |||||
| November 9 | Introduction to resistance in Plasmodium |
White, J Clin Invest 2004 White, Science 2008 Dondorp et al., New Engl J Med 2009 |
Jan Engelstädter |
Katja Leicht Christophe Borel |
[pdf] [pdf] |
| November 16 |
Adaptive Copy Number Evolution in Plasmodium Evolution-proof insecticides against mosquitoes |
Nair et al., PLoS Genetics 2008 Read et al., PLoS Biology 2009 |
Jan Engelstädter |
Dorota Paczesniak Séverine Büchel |
[pdf] [pdf] |
| 4) Agricultural pests | |||||
| November 23 | Resistance in fungi |
Verweij et al., Lancet Infect Dis 2009 Metcalfe et al., Plant Pathol 2000 |
Bruce McDonald |
Ramona Rudolf von Rohr Kathrin von Arx |
[pdf] [pdf] |
| November 30 | Resistance in fungi |
Ma et al., Crop Protection 2005 Torriani et al., Pest Managment Science 2009 |
Bruce McDonald |
Rebecca Gau Stella Koch |
[pdf] [pdf] |
| 5) Cancer | |||||
| December 7 |
Introduction Environment-mediated resistance |
Merlo et al., Nat Rev Cancer 2006 Meads et al., Nat Rev Cancer 2009 |
Pia Abel zur Wiesch |
Tamara Kleiner Dominique Cadosch |
[pdf] [pdf] |
| December 14 |
Multidrug resistance Optimal number of drugs |
Szakacs et al., Nat Rev Drug Discov 2006 Komarova & Wodarz, PNAS 2005 |
Pia Abel zur Wiesch |
Viola Cassina Rafal Mostowy |
[pdf] |
| December 21 | Concluding discussion | ||||
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